Pengobatan Glioblastoma Multiforme Saat Ini dan Masa Depan: Literature Review

نویسندگان

چکیده

Glioblastoma multiforme (GBM) ditandai dengan pertumbuhan yang cepat dan invasi difasilitasi oleh migrasi sel degradasi matriks ekstraseluler. Meskipun GBM adalah tumor langka insiden secara global kurang dari 10 per 100.000 orang, prognosisnya buruk tingkat kelangsungan hidup 14-15 bulan setelah diagnosis menjadikannya masalah kesehatan penting. Pasien terdiagnosis memiliki presentasi klinis muncul akibat mekanisme langsung (primer) tidak (sekunder) karena peningkatan tekanan intrakranial. Saat ini, metode diagnostik untuk mendeteksi mengandalkan tes neurologis neuroimaging. Segera ditemukan adanya pada sistem saraf otak maka dilakukan pembedahan sebagai bentuk terapi histopatologis. Tujuan meninjau mengenai tatalaksana terkini memaksimalkan pemulihan, meminimalisir efek samping memperpanjang angka harapan pasien. Penelitian ini merupakan tinjauan literatur. Database online utama (Perpustakaan Cochrane, PubMed, Science Direct) dicari menggunakan kata kunci berikut (“GBM” ATAU “glioblastoma multiforme”) DAN (“treatment) dipersempit lebih jauh ke jurnal diterbitkan dalam tahun terakhir. Perawatan khusus glioblastoma melibatkan reseksi bedah massa tumor, diikuti perawatan radioterapi kemoterapi.

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ژورنال

عنوان ژورنال: Jurnal Farmasetis

سال: 2023

ISSN: ['2252-9721', '2549-8126']

DOI: https://doi.org/10.32583/far.v12i2.1207